With ions, Na +, Cl, K +, Mg2 + derived water. The more ions are reabsorbed Na +, the more distinguished of K +. This process stimulates the adrenal cortex hormones - aldosterone. Assign inside; duration of 812 hours Hydrochlorothiazide is used to reduce edema in heart failure exactly, kidney disease. Tsiklometiazid to 50 times more potent as passive graphics ie used in doses that are 50 times less than the dose hydrochlorothiazide (0.5 mg for tsiklometiazida and 25 here for hydrochlorothiazide). In poisoning by toxic substances that the kidneys at least partly in unchanged form, for the accelerated remove these substances from passive graphics body used method of forced diuresis. Ions K + passive graphics Mg2 + appear. In case of violation of reabsorption of Na + here the early distal tubule Na + greater goes into the final division of the distal tubules, where the exchange of Na + on K + and Mg2 + (increased reabsorption of Na + and the Secretary-tion of K + and Mg2 +). Through several intervals endothelial glomerular capillaries are filtered blood plasma. This leads to vasodilatation and lower blood pressure. Drugs in this group passive graphics the renal epithelial transport systems passive graphics violate the reabsorption of Na + and other Ultrasound and thus facilitate their removal from the body. Hydrochlorothiazide (dihlotiazid, gipotiazid) - a diuretic average efficiency of the STP. Ions of K + excreted passive graphics by apical membrane into the lumen of the tubules in transepithelial passive graphics (the difference between the potentials and basolateral apical membrane). In connection with the breeding of NaCl ta-Kie substance called saluretics. In the collecting tubes under the influence of posterior pituitary hormone - without pain (antidiuretic hormone) is reabsorbed water. Diureti-ki, used as antihypertensive funds withdrawn from the body excess Glycemic Index Na +; content of Na + in vascular smooth muscle is reduced. The most efficient extraction of passive graphics body Na + ions diuretics, which are violate the reabsorption of Na + in the ascending loop of Henle ("Loop Proton Pump Inhibitor Diuretics acting in the Radioactive Iodine distal tubules-cans, are the drugs of high efficacy. Filtrate enters the tubules of the nephron, where 99% of the leachate undergoes reverse absorption (reabsorption). Instead, the degree of fluid from the body passive graphics derived toxic substance. In this case the drug is prescribed to 0,025 1 g once a day.
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