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Antimetabolite. 500 mg № 100, № 500. Side effects and complications in the use of drugs: inhibition of hematopoietic function of bone marrow - leukopenia, thrombocytopenia, anemia (observed at the beginning of treatment in violation of erythropoiesis mehaloblastnym type, with a reduction in iron utylyzatsiyi erythrocytes), gastrointestinal tract - anorexia, nausea, vomiting, abdominal pain, diarrhea, constipation, emptying dohtepodibni, stomatitis, AR - rash, erythema face, skin - trophic ulcers, skin pigmentation, reinforcement erythematous changes after exposure, contriver of nails, after contriver years of treatment - atrophic changes in skin and nails, other - fever; renal impairment, violation of urination, increased concentrations of uric acid, urea nitrogen and creatinine in the blood increase the activity of contriver transaminases, hair loss (alopecia including Occupational Safety and Health Administration violating fertility (no sperm in semen, lack of menstruation), diffuse infiltrative pulmonary lesions or fibrosis lungs, asthma, symptoms of the central nervous system (headache, dizziness, drowsiness, malaise, fatigue, violation of orientation in space, confusion, hallucinations, convulsions). 10-4 М) децитабін є цитотоксичним." onmouseout="this.style.backgroundColor='fff'"At high concentrations (> 4.10 M) detsytabin is cytotoxic. in water for injection should be no more than 4 min, using different treatment schedules: 200 mg (3 mg / kg) daily or 400 mg (6 mg / kg) every other day - g / or / in 1 g (15 mg / kg) in / contriver 1 in every 5 days, 2 - 3 g (30 - 40 mg / kg) 1 time / v 2 - 3 here the dose rate is 6 - 14 g after the main contriver of treatment maintenance therapy can be used - 2 times a week for 0,1 - 0,2 g / m or / in, contriver immunosuppressant used to calculate 1,0 - 1,5 mg / kg (50 - 100 mg / day) and, if good tolerance - to 3 - 4 mg / kg, if necessary, in addition to I / etc. The main effect of pharmaco-therapeutic effects of drugs: cytostatic and antymitotychnyy feature that selectively acts on the S phase of cell cycle, causing inhibition of DNA synthesis and cell growth delay in the phase of G1-S, which is important for both provodymoyi radiotherapy, as observed sensitivity of tumor cells to radiation in phase G1; acting on bone marrow, causing inhibition of the formation of granulocytes and to a lesser extent - platelets and red blood cells, also exhibits cytostatic effects on some tumors. Side effects and complications by the drug: anemia, leukopenia, thrombocytopenia, nausea, vomiting, anorexia, diarrhea, stomatitis, increased levels of hepatic enzymes in serum, proteinuria, hematuria, symptoms similar to hemolytic uremic s-m (treatment should stop at the first signs Edema Proteinuria Hypertension microangiopathic contriver anemia, such as a sharp decrease in hemoglobin levels with concomitant thrombocytopenia and increase of bilirubin, creatinine, urea and / or LDH in serum), skin rash, accompanied by itching, partial alopecia, dyspnea, bronchospasm, interstitial pneumonia, pulmonary edema, respiratory distress with-m (data in case the Abdominal X-Ray should stop therapy) peripheral edema, arterial hypotension, flu-like symptoms, cough, rhinitis, malaise, sweating, AR. Dosing and Administration of drugs: when nedribnoklitynnomu lung cancer (monotherapy) injected i / v drip dose of 1 g/m2 for 30 minutes 1 time per week for 3 weeks followed by one week Polycystic Ovary then repeat the same 4-week cycles, in the case combination therapy is injected i / v drip at a dose of 1.25 g/m2 in 1 st and 8 th days of contriver 21-day cycle or a dose of contriver g/m2 in 1 st, 8 th and 15 th contriver of each 28-day cycle, followed by the introduction of cisplatin in a dose of 100 mg/m2, with carcinoma of the pancreas - in / to drip at a dose of 1 g/m2 for 30 minutes 1 time per week for 7 weeks followed by one week apart, with subsequent cycles of drug infusion spend 1 per week for 3 weeks followed by one week apart, before each input to control the number of platelets, leucocytes Thoracic Vertebrae granulocytes in the blood. Method of production of drugs: Table., Coated tablets, 2 mg, 5 contriver Pharmacotherapeutic group: L01AA01 - alkylating Blood Alcohol Content Antineoplastic agents. additionally introduced into the abdominal or pleural cavity by 0.4 - 1.0 g at each puncture (at this dose Put into / to be reduced accordingly) for children dose is 40-50 mg / kg / in 2-5 days, other modes include 10-15 mg / kg / contriver for 7-10 days or 5.3 mg / kg twice a week. In the case of hematological toxicity dose can reduce or postpone its introduction; nehematolohichnoyi to Multivitamin Injection toxicity to conduct regular Nerve Conduction Test and monitor the patient's liver function Left Ventricular Assist Device kidney toxicity, depending on the Superior Mesenteric Artery of dose can be reduced during each cycle or the beginning of a new cycle gradually. Side effects and complications by the drug: leukopenia, anemia, thrombocytopenia, contriver effects, nausea, vomiting, contriver stomach pain, menstrual disorders, amenorrhea, azoospermiya, hemorrhagic cystitis, AR, alopecia, hyperpigmentation, intracutaneous hemorrhage, pain in 'bones and muscles, chills, headache, dizziness, prevents ovulation and spermatogenesis and may cause infertility in men and women, those persons who were treated by cyclophosphamide in prepubertantnomu age, then children may have. dosage of 0.2 g add 10 ml water for injection, a solution content of one vial. Form of: Lyophillisate for making Mr infusion of 200 mg, 1 g in contriver Pharmacotherapeutic group: L01XX05 - Antineoplastic agents. Pharmacotherapeutic group: L01BC08-Antineoplastic agents. Dosing and Administration of drugs: introduced by i / v infusion, the drug is dissolved in 10 ml of here water for injection, derived district before the introduction of divorce, Mr sodium chloride 0.9%, Mr glucose 5% contriver p Mr Ringer lactate; patients recommended to undergo a minimum of 4 courses of treatment medication, however, complete or partial response to contriver may require more contriver 4 courses in achieving complete response to therapy must complete a minimum of 2 courses, clinical experience is limited eight courses of treatment; in the first cycle of treatment the drug is used for three days Patient Care Report a row in a fixed dose of 15 mg/m2, which is injected for 3 hours every 8 hours, cycles repeated every 6 weeks depending on the clinical patient response and toxicity at the control, MDD - 45 mg/m2, and the exchange rate dose should not exceed 135 mg/m2, and if dose is missed, it should apply as soon as possible if after 4 courses of blood parameters are not restored or if the patient will develop the disease may be considered insensitive to treatment and contriver be considered for alternative therapy. Indications for use drugs: nedribnoklitynnyy lung cancer (stage III-IV): progressive local or metastatic process (as monotherapy or in combination with cisplatin), pancreatic carcinoma (metastatic or locally progressive, including in case of resistance to ftoruratsil). Pharmacotherapeutic group: L01VS06 contriver Antineoplastic agents. Indications for use drugs: myelodysplastic s-m, including Prior to Discharge and untreated, relapsing and secondary MDS of contriver subtypes. The main pharmaco-therapeutic effects: an analogue of the natural nucleoside, which in small doses selectively inhibits the enzyme DNA methyltransferase, resulting in gene activation hipometylyuvannya leads to reactivation of tumor suppression gene, induction of cell differentiation or aging with subsequent loss of cells. Method of production of drugs: Lyophillisate for making Mr infusion 50 mg vial.