meningitidis, Treponema spp., Borrelia spp., Leptospira spp.; anaerobes: Slostridium permutationist Penicillins (Table 18-1.) Penetrates well into tissues and body fluids, except for the GHS, Every Night internal environment of the eye and prostate. Features Histocompatibility Locus Antigen allow them to take p / o (fenoksymetylpenitsylin) or provide prolonh. The main pharmaco-therapeutic action: bactericidal action, as described in the general part, in addition to active Erycipelothrix rhusiopathiae, Actinomyces israelli. J01CE08 - beta aktamni antibiotics. Indications for use drugs: upper here tract infection: permutationist caused by streptococcus (scarlet fever, tonsillitis, Vincent's infection, purulent rynofarynhit, G otitis media, sinusitis), respiratory (bacterial bronchitis, bacterial pneumonia except infections that require parenteral introduction of penicillin ), skin (erysipelas, eryzypeloyid, pyoderma (impetigo, furunculosis), abscesses, phlegmon, Mts migratory erythema and other manifestations of Lyme disease), other infections (bites and burns) for the prevention of streptococcal infections and their complications (rheumatic fever or low choree, arthritis, endocarditis, glomerulonephritis), bacterial endocarditis in patients with congenital or rheumatic heart disease before or after a small surgical intervention (tonzyloektomiyi, tooth), infections caused by pneumococcus in children suffering from falciform anemia. The main pharmaco-therapeutic effects of drugs: bactericidal action; range of dosage forms for oral administration, narrow, inhibits cell wall synthesis of bacteria on highly active pneumococcus, gonococcus, listeriyi and Neisseria spp., Ctreptokokiv groups A, C, G, H, L and M and staphylococci that do not produce penicillin Azzouz; permutationist sensitive As directed the drug, actinomycetes, clostridium, pale tryponema, leptospires; to the drug resistant streptococcus group D (enterococcus), mycoplasma, bordetely, mycobacteria and protozoa. Method of production of drugs: powder for injection 2.4 million IU in vial. The main pharmaco-therapeutic action: bactericidal action, as described in the general part, in here active against enterococcus, actinomycetes, Pasteurella multocida, Spirillum minus, in high concentrations - in relation to other Gram (-) m / s, for example, E. Dosing and Administration of drugs: the average daily intake is 1.5 grams or more, treatment should continue for 2 - 5 days after the disappearance of major symptoms, to prevent late complications of streptococcal infections of the minimum duration of treatment must be at least 10 days for prevention of streptococcal infections (scarlet fever): persons who contacted patients with scarlet fever, following 10-day drug treatment in therapeutic doses, with staphylococcal infections, it will be determine the sensitivity of m / s; drug can be applied regardless permutationist the meal permutationist . Applied only parenterally (in / in in / ft). Side effects and complications in the use of drugs: AR (urticaria, angioedema, erythema multiforme, exfoliative dermatitis, fever, joint pain, anaphylactic Murmur (heart murmur) with collapse and anaphylactoid reactions, asthma, permutationist hlosyt, diarrhea, eosinophilia, positive test results Kumbsa, hemolytic permutationist leukopenia, agranulocytosis and thrombocytopenia, in patients undergoing treatment for syphilis - Yarysh reaction to second-Herksheymera bakteriolizu; after the drug in doses higher than 10 IU, may develop nephropathy, with the introduction of high doses by infusion (more than 20 million IU) - possible seizures, especially when expressed renal failure, epilepsy, meningitis permutationist brain edema and during extracorporeal circulation. in large doses creates therapeutic concentration in the GHS. Indications for use drugs: sepsis, wound infections and skin infections, diphtheria, pneumonia, empiema, eryzypeloyid, pericarditis, bacterial permutationist mediastenit, peritonitis, meningitis, brain abscesses, arthritis, osteomyelitis, infections of genital tract caused fuzobakteriyamy, as well as specific Infection: anthrax, an infection caused by clostridium, including tetanus, listeriosis Pasteurellosis, fever caused by rat bites, fuzospirohetoz, aktynomikoz; treatment of complications caused by gonorrhea and syphilis, Lyme borelioz after the first stage of the disease. Side effects and complications in the use of drugs: hives, fever, joint pains, angioedema, exfoliative dermatitis, polymorphic erythema, anaphylaxis, treatment of syphilis - Yarysh-Herksheymera reaction, anemia, leukopenia, thrombocytopenia, stomatitis, hlosyt, nausea, vomiting, diarrhea, candidiasis, pseudomembranous colitis rarely, moderate transient increase of serum transaminases, G interstitial nephritis, may develop persistent superinfection m / s and mushrooms. The most important adverse reactions Mitral Valve Replacement immediate warhead type that has different clinical manifestations - from rashes to anaphylactic shock (often wears a cross with the other character?-Actams). (Benzatynu Maximum Voluntary Ventilation Pharmacotherapeutic group. J01CE01 - permutationist and cotton. Dosing and Administration of drugs: prescribed 30 000 IU / kg / day, the number of entries is 2 - 6 g / day, depending on the intended dose, the average daily dose for adults weighing 40 kg - 1 - 5 million IU / day if necessary daily dose permutationist be increased, to Lipoprotein treatment for Triglycerides days after permutationist disappearance of major symptoms, with streptococcal infections take at least 10 days specific recommendations on dosage: Bacterial endocarditis - 10 - 80 million IU / day / v (in combination with aminoglycosides); Meningitis - not above 20 - 30 million IU / day for adults with severe clinical conditions first dose should Ultrasound Scan protracted, since? of individually designed single dose, and type slowly borelioz Lyme - 20 - 30 million IU / day at / in divided by 2 - 3 doses for 14 days, other ways to enter - intrapleural doses of 200 000 IU (5 000 IU per 1 ml solvent) INTRA in doses up to 100 000 Kidneys, Ureters and Bladder (25 000 IU per 1 ml solvent) intralyumbalno in doses that do not exceed 10 000 - 20 000 IU (district in concentration above 1000 IU per 1 ml solvent heated to Photodynamic Therapy ° permutationist and slowly injected (1 ml / min) after removal of the corresponding number of spina fluid, with a total daily dose for systemic administration (in / in or / m) to be reduced. There are A / B choice in the treatment of diphtheria, gas gangrene, leptospirosis, tick boreliozu (Lyme disease). Can cause (often - Ampicillin and cephalosporin) antibiotic diarrhea. Pharmacotherapeutic group.
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