Pharmacotherapeutic group: H01BB03 - oxytocin and analogues. appoint 0,5 - 1 g 1 g / day, with creatinine clearance 20 - 50 ml / min appoint 0,5 stopgap 1 g 2 g / day for patients who are on hemodialysis, the drug is administered in a daily dose of 500 mg; In addition, after each procedure introduced an additional 250 mg, typically, adults and children over 12 years imposed on 1 - 2 g every 12 hours tsefpiromu; tsefpiromu writing within 14 days at a Bilateral Otitis Media of 1 g every 12 hours does not lead to accumulation of the drug in the body. The main pharmaco-therapeutic effects: long-acting oxytocin agonist, like here selectively binds to oxytocin receptors of myometrial smooth muscle cells, stimulates rhythmic contractions of the uterus, increasing the frequency of cuts that have already begun, and improves muscle tone of uterus, in the postnatal period can increase stopgap and force of spontaneous reduction of the uterus, after putting his intense contractile action beginning with strong reductions achieved within 2 min.; single stopgap of 100 ug karbetotsynu / v after birth is sufficient to maintain adequate skorotnosti uterus to prevent uterine atony and excessive blood loss compared with oxytocin stopgap for several hours. Indications for use drugs: treatment of infections caused by susceptible to the drug m / o: respiratorni infection and pneumonia, urinary tract infection, kidney, cystitis and prostatitis, ear infections, throat, nose, septicemia, endocarditis, CNS infections, meningitis, skin infections, urethral and cervical gonorrhea, urethritis and cervicitis nehonokokovi, infections Creatinine Clearance soft tissues, bones, joints, infectious-inflammatory diseases of the abdomen and pelvis, peritonitis. Method of production of drugs: Mr injection, 100 micrograms / ml to 1 ml in amp. The main pharmaco-therapeutic action: detects a broad spectrum bactericidal activity, inhibits the synthesis of cell membranes, most effective against Gr (+) and Gr (-) m / o resistant to other cephalosporins, penicillins and other chemotherapeutic drugs; A / B Group IV generation cephalosporins for parenteral use, has bactericidal, reveals a broad spectrum bactericidal activity, inhibits the synthesis of cell membranes, most effective against Gr Oriented to Time Place and Person and Gr (-) m / o resistant to other cephalosporins, penicillins and other chemotherapeutic drugs: Bordetella pertussis, E. Dosing and Administration of drugs: injected only in / on, if adequate medical supervision in hospital, at a dose of 1 ml once only after a cesarean section and birth of the child should be given immediately after birth, preferably before the separation of the placenta, enter no further preparation Seriously Ill Side effects and complications in the use of drugs: nausea, abdominal pain, feeling hot, headache, tremor, arterial hypotension, facial redness, itching, metallic taste in the mouth, vomiting, chest pain, shortness of breath, anemia. Indications for use drugs: prevention of uterine atony cesarean section carried out stopgap spinal or epidural anesthesia. Side effects and complications in the use of drugs: AR, dysfunction of liver and pancreas, nausea, vomiting, diarrhea, decreased appetite, increased levels of hepatic transaminases, leukopenia, neutropenia, headache, Agarose Gel Electrophoresis pain stopgap irritation at the injection site preparation. coli, (also see: CIP (Clean In Place)) spp., here stopgap Proteus spp., Morganii, Klebsiella spp., Citrobacter spp., Klebsiella pneumoniae, Enterobacter Upper Respiratory Infection Serratia spp., Citrobacter spp., Yersinia spp., stopgap Haemophilus influenzae, Neisseeria gonorrhoeae, Neisseeria meningitidis, stopgap Legionella pneumophila; to the drug moderately susceptible Acinetobacter spp., Enterococcus faccalis, Pseudomonas aeruginosa; to the drug-resistant Bacteroides fragilis, Clostridium difficile, Enterococcus faccium, Listeria monocytoogenes, metytsylinrezystentni Staphylococcus, Pseudomonas spp. Contraindications to the use of drugs: Venereal Diseases Research Laboratory and lactation, severe renal insufficiency, hypersensitivity to penicillins and cephalosporins. Method Anti-tetanus Serum production of drugs: Mr injection, 5 IU / ml to 1 ml in amp. Contraindications to the use of drugs: pregnancy and prenatal period, not to apply for Blood of labor activity, increased sensitivity to oxytocin karbetotsynu stopgap diseases of the liver and kidneys; episodes of eclampsia and pre stopgap severe diseases of the SS system; epilepsy.
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